V-pipe is a bioinformatics pipeline for the analysis of next-generation sequencing data derived from intra-host viral populations.

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bio.tools ExPASy License: Apache-2.0


Introduction

Virus populations exist as heterogeneous ensembles of genomes within their hosts. This genetic diversity is associated with viral pathogenesis, virulence, and disease progression, and it can be probed using high-throughput sequencing technologies. V-pipe is a bioinformatics pipeline for the analysis of viral genomic data that allows for assessing intra-host viral genetic diversity. Integrating various open-source software packages, V-pipe supports quality control, read mapping, error correction, and viral haplotype reconstruction. It provides standardized, transparent, and reproducible workflows for research and diagnostic applications.

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